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KMID : 1148120210110020074
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Journal of Advanced Spine Surgery
2021 Volume.11 No. 2 p.74 ~ p.79
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Efficacy and Safety of Anorganic Bone Matrix/P-15 in Posterior Lumbar Interbody Fusion
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Park Sang-Man
Jeong Yeong-Ha
Ha Byeong-Jin
Yoo Beom-Seok
Kim Soo-Heon
Lee Chang-Kyu
Shin Dong-Ah
Yi Seong
Ha Yoon
Kim Keung-Nyun
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Abstract
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Objective: To evaluate the efficacy and safety of anorganic bone matrix (ABM)/P-15 compared with local autograft bone in posterior lumbar interbody fusion (PLIF) with pedicle screws for degenerative lumbar diseases.
Methods: This is a retrospective analysis of consecutive series of 138 patients undergoing 1 or 2 levels PLIF from 2015 to 2020 in our single institute. Local autograft bone or ABM/P-15 (i-factor, Cerapedics Inc., Westminster, Colorado USA) were used for interbody fusion. The successful fusion was defined as the segmental cobb angle of less than 5 degrees of in flexion/extension X-rays and continuity of the trabecular bony bridging in computed tomography (CT) images.
Results: Among a total of 138 patients, total levels of fusion were 202, of which 74 were in 1 level fusion and 128 were in 2 level fusion. And 93 used ABM/P-15 and 109 used local autograft bone. The evaluation time of fusion status was 1 year after surgery. Successful fusion based on X-ray images was achieved 84.1% (90/107) for local autograft bone and 91.3% (84/92) for ABM/P-15 (p=0.127). Based on CT images, 86.9% (93/107) of autograft group and 95.6%(87/91) of AMP/P-15 group showed successful fusion respectively (p=0.034). Occurrence rate of autolysis was 14% (15/107) for local autograft bone and 17.6% (16/91) for ABM/P-15. Subsidence rates were 11.2% (12/107) for local autograft bone and 9.99% (9/91) for ABM/P-15. Hollow formation around pedicle screw was noted in 9.3% (10/107) for local autograft bone and 2.2% (2/91) for ABM/P-15.
Conclusions: The use of AMP/P-15 for lumbar interbody fusion surgery can be a good substitute for local autograft bone in terms of better fusion rate and similar complication rate on radiologically.
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KEYWORD
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Posterior spinal fusion, AMP/P-15, Autograft
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